傳統(tǒng)動物心電圖測量分析采用體表方式，雖操作簡單，但是存在測量位置影響大、測量精度不高等局限性，而心外膜表面電極測量心電圖操作極為復雜且創(chuàng)傷性大，實驗中較少采用。為解決這一難題，Scisence 提供微創(chuàng)的多電極電生理導管，設計使研究者能夠對生物電在整個心臟的擴散過程進行更為深入的測量和分析。

電生理導管系統(tǒng)由八電極電生理導管、電極分配盒及第三方生物電放大器及刺激器組成。

工作原理：八電極電生理導管上的每對電極均獨立受控于電極分配盒，電極分配盒通過 2mm 針式連接線與第三方生物電放大器或刺激器相連，通過采集對應的電極對引導的電信號數(shù)據(jù)。八電極電生理導管可用于心臟起搏，電信號記錄，進而用于心臟電生理的各方面研究。

電生理導管工作原理圖

心臟電生理導管需要插入大鼠、小鼠等動物的心臟內(nèi)部，測量和紀錄心房及心室的電生理信號：傳導時間、不應期、希氏束電位、竇房結和房室結功能、心律失常的誘導。 

LabScribe 心電分析模塊

5. 可輕松提取源數(shù)據(jù)或平均數(shù)據(jù)作為圖片或文本導出；

6. 可選 ASCII 文本導入模塊將其他第三方設備采集的 ECG 數(shù)據(jù)導入本軟件進行分析；

 

LabScribe 進行心電分析

相關文獻：

1. Luo X, et. al. “MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation." J Clin Invest. 2013 May 1; 123(5): 1939-51
2. De Jong AM, et. al. “Atrial remodeling is directly related to end-diastolic left ventricular pressure in a mouse model of ventricular pressure overload." PLoS One. 2013 Sep 6; 8(9): e72651
3. Guasch E, et. al. “Atrial fibrillation promotion by endurance exercise: demonstration and mechanistic exploration in an animal model." J Am Coll Cardiol. 2013 Jul 2;62(1):68-77
4. Cardin S, et. al. “Role for MicroRNA-21 in atrial profibrillatory fibrotic remodeling associated with experimental postinfarction heart failure." Circ Arrhythm Electrophysiol. 2012 Oct; 5(5): 1027-35
5. Iwasaki YK, et. al. “Determinants of atrial fibrillation in an animal model of obesity and acute obstructive sleep apnea." Heart Rhythm. 2012 Sep; 9(9): 1409-16.e1
6. Jiao KL, et. al. “Effects of valsartan on ventricular arrhythmia induced by programmed electrical stimulation in rats with myocardial infarction." J Cell Mol Med. 2012 Jun; 16(6): 1342-51
7. Zhou Y, et. al. “Matrine inhibits pacing induced atrial fibrillation by modulating I(KM3) and I(Ca-L)." Int J Biol Sci. 2012; 8(1): 150.
8. Benito B, et. al. “Cardiac arrhythmogenic remodeling in a rat model of long-term intensive exercise training." Circulation. 2011 Jan 4; 123(1): 13-22
9. Prestia KA, et al. “Increased Cell-Cell Coupling Increases Infarct Size and Does not Decrease Incidence of Ventricular Tachycardia in Mice." Front Physiol. 2011 Jan 31; 2(1): 1-7
10. Aubin MC, et al. “A high-fat diet increases risk of ventricular arrhythmia in female rats: enhanced arrhythmic risk in the absence of obesity or hyperlipidemia." J Appl Physiol. 2010 Feb; 108: 933-940
11. Lu Y, et al. “MicroRNA-328 contributes to adverse electrical remodeling in atrial fibrillation." Circulation. 2010 Dec; 122(23): 2378-87
12. Mathur N, et al. “Sudden infant death syndrome in mice with an inherited mutation in RyR2." Circ Arrhythm Electrophysiol. 2009 Dec; 2: 677-685

     

    

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